Version7c, December 2005

J. Garcia de la Torre, M.L. Huertas and B. Carrasco, "Calculation of hydrodynamic properties of globular proteins from their atomic-level structure. Biophys. J. 78, 719-730 (2000)

HYDROPRO computes the hydrodynamic properties of rigid macromolecules (globular proteins, small nucleic acids, etc) from their atomic-level structure, as specified by the atomic coordinates taken from a PDB file supplied by the user, from which the proper hydrodynamic model is built by the program itself. The HYDROPRO calculation comprises was the basic hydrodynamic properties: translational diffusion coefficient, sedimentation coefficient, intrinsic viscosity, and relaxation times, along with the radius of gyration. Optionally, HYDROPRO computes also other solution properties such as the covolume (related to the second virial coefficient) and scattering related properties such as the angular dependence of scattering intensities and the distribution of intramolecular distances. Beware that we have another similar program – HYDRONMR – for the more specific purpose of calculating quantities relevant in NMR relaxation.

For more details, see the HYDROPRO User Guide